Retinol

Short Description:

Cosmate®RET, a fat-soluble vitamin A derivative, is a powerhouse ingredient in skincare renowned for its anti-aging properties. It works by converting to retinoic acid in the skin, stimulating collagen production to reduce fine lines and wrinkles, and accelerating cell turnover to unclog pores and improve texture.

Trade Name: Cosmate®RET

Product Name: Retinol

INCI Name: Retinol

Molecular Formula: C20H30O

CAS No.: 68-26-8

Online Messages Email WhatsApp

Product Detail

Why Zhonghe Fountain

Product Tags

Retinol, a derivative of vitamin A, is a widely celebrated skincare ingredient renowned for its versatile benefits. As a fat-soluble compound, it penetrates the skin’s layers to exert its effects, primarily by converting into retinoic acid, which interacts with skin cells to trigger biological changes.

Its key functions include stimulating collagen production, which helps reduce fine lines, wrinkles, and sagging, thereby enhancing skin elasticity. It also accelerates cell turnover, sloughing off dead skin cells to unclog pores, refine texture, and fade hyperpigmentation or dark spots, resulting in a brighter, more even tone.

Commonly found in serums, creams, and treatments, retinol is suitable for most skin types but requires cautious use—initial application may cause dryness, redness, or sensitivity, so gradual introduction (e.g., starting 1-2 times weekly) is advised. It also increases sun sensitivity, making daily sunscreen mandatory.

Due to its instability in light and air, it’s often packaged in dark, airtight containers. Pregnant or breastfeeding individuals are typically advised to avoid it. With consistent, long-term use, retinol remains a cornerstone in anti-aging and skin-rejuvenation routines.

Benefits of rentiol：

Multifunctional efficacy: As a bioactive vitamin A derivative, it addresses multiple skin concerns in a single ingredient—stimulating collagen synthesis to combat aging, accelerating keratinocyte turnover to improve texture, and regulating melanin to correct discoloration. This versatility reduces the need for complex, multi-ingredient blends.
Dermal penetration: Its molecular structure allows it to penetrate the epidermis and reach the dermis, where it acts on fibroblasts (collagen-producing cells), making it more effective than surface-level exfoliants for long-term skin health.
Formulation flexibility: Compatible with various bases (serums, creams, oils) when stabilized with antioxidants (e.g., vitamin E) or in encapsulated forms, enabling inclusion in diverse product types for different skin needs (e.g., lightweight serums for oily skin, richer creams for dry skin).
Proven clinical backing: Extensive research supports its ability to deliver visible results (reduced wrinkles, improved elasticity) with consistent use, enhancing product marketability and consumer trust.
Synergistic potential: Works well with other ingredients like hyaluronic acid (to counter dryness) or niacinamide (to boost barrier function), allowing formulators to create balanced, efficacy-driven products.

Rentiol mechanism of Action：

Retinol’s mechanism of action in skincare is rooted in its role as a vitamin A derivative, involving a series of biological processes that target multiple skin layers:

Penetration and activation: When applied topically, retinol penetrates the epidermis (outer skin layer) and is enzymatically converted into retinoic acid—its biologically active form—by skin cells (keratinocytes and fibroblasts).
Nuclear receptor interaction: Retinoic acid binds to specific receptors in cell nuclei: retinoic acid receptors (RARs) and retinoid X receptors (RXRs). This binding triggers changes in gene expression, regulating cellular activity.
Cell turnover acceleration: It stimulates the production of new keratinocytes (skin cells) in the basal layer of the epidermis while speeding up the shedding of dead cells from the stratum corneum. This reduces congestion, unclogs pores, and improves texture, leading to smoother, brighter skin.
Collagen and elastin synthesis: In the dermis (deeper skin layer), retinol activates fibroblasts—cells responsible for producing collagen (types I and III) and elastin. This strengthens the skin’s structural framework, reducing fine lines, wrinkles, and sagging.
Melanin regulation: It inhibits the transfer of melanin (pigment) from melanocytes to keratinocytes, gradually fading hyperpigmentation, dark spots, and uneven tone.

Sebum modulation: It can regulate sebaceous gland activity, reducing excess oil production, which helps prevent acne and minimizes the appearance of enlarged pores.

This multi-layered action makes retinol a powerful ingredient for anti-aging, texture refinement, and tone correction, though its potency requires careful, consistent use to avoid irritation.

Advantages of Rentiol

1. Comprehensive Skin Rejuvenation

Retinol addresses multiple skin concerns simultaneously, making it highly efficient:

Anti-aging: Stimulates collagen and elastin production in the dermis, reducing fine lines, wrinkles, and sagging by strengthening the skin’s structural support.
Texture Improvement: Accelerates keratinocyte turnover (the shedding of dead skin cells and production of new ones), unclogging pores, smoothing rough patches, and revealing a softer, more refined surface.
Tone Correction: Inhibits melanin transfer from pigment-producing cells (melanocytes) to skin cells (keratinocytes), gradually fading dark spots, hyperpigmentation, and post-inflammatory marks, resulting in a more even complexion.

2. Dermal Penetration & Targeted Action

Unlike many surface-level ingredients, retinol’s molecular structure allows it to penetrate the epidermis (outer skin layer) and reach the dermis (deeper layer), where critical structural changes (e.g., collagen synthesis) occur. This deep action ensures long-term, visible improvements rather than temporary surface effects.

3. Proven Efficacy with Clinical Backing

Extensive scientific research and clinical studies validate its effectiveness. Data consistently shows that regular use (over weeks to months) leads to measurable improvements in skin elasticity, wrinkle depth, and pigmentation—building consumer trust in formulations containing retinol.

4. Formulation Versatility

Compatible with various skincare formats, including serums, creams, gels, and overnight treatments, adapting to different skin types (e.g., lightweight serums for oily skin, richer creams for dry skin).
Works synergistically with other ingredients: Pairing with hyaluronic acid counteracts dryness, while niacinamide enhances barrier function, allowing formulators to create balanced, irritation-mitigated products.

5. Long-Term Skin Health Benefits

Beyond cosmetic improvements, retinol supports overall skin health by:

Strengthening the skin barrier (over time, with consistent use) by promoting healthy cell turnover.
Regulating sebaceous gland activity, reducing excess oil and lowering the risk of acne breakouts.

Technical Parameters:

Parameter	Details
Molecular Formula	C₂₀H₃₀O
Molecular Weight	286.45 g/mol
CAS Number	68 – 26 – 8
Density	0.954 g/cm³
Purity	≥99.71%
Solubility (25℃)	57 mg/ml (198.98 mM) in DMSO
Appearance	Yellow – orange crystalline powder