Pyrroloquinoline Quinone(PQQ)

Pyrroloquinoline Quinone (PQQ) is a naturally occurring, vitamin-like compound found in soil, plants, and certain foods (like kiwifruit, spinach, and fermented soybeans). It functions as a potent redox coenzyme, playing a critical role in cellular energy production, antioxidant defense, and cell signaling pathways. Unlike most antioxidants, PQQ actively promotes the generation of new mitochondria (mitochondrial biogenesis), particularly in energy-demanding organs like the brain and heart. Its unique ability to undergo thousands of redox cycles makes it exceptionally effective in combating oxidative stress and supporting fundamental biological processes for optimal health and longevity.

• Key Function of PQQ:
  Stimulates mitochondrial biogenesis and optimizes energy (ATP) production within cells.
• Mitochondrial support & energy boost: Stimulates mitochondrial biogenesis (increasing their number), enhances mitochondrial function, and improves cellular energy production, helping alleviate fatigue.
• Powerful antioxidant activity: Neutralizes free radicals effectively, reduces oxidative stress, and protects cells from damage caused by reactive oxygen species.
• Neuroprotective effects: Promotes the synthesis of nerve growth factors, supports the growth and survival of neurons, and may enhance cognitive functions like memory and focus.
• Anti-inflammatory properties: Inhibits the release of pro-inflammatory factors, helping reduce chronic inflammation linked to various diseases.
• Metabolic regulation: May improve insulin sensitivity, aid in blood sugar and lipid balance, and support overall metabolic health.
• Mechanism of Action:
• Redox Cycling: PQQ acts as a highly efficient electron carrier, undergoing continuous reduction and oxidation (20,000+ cycles), far exceeding common antioxidants like Vitamin C. This neutralizes free radicals and reduces oxidative stress.
•  Mitochondrial Biogenesis: PQQ activates key signaling pathways (notably PGC-1α and CREB) that trigger the creation of new, healthy mitochondria and enhance the function of existing ones.
•  Nrf2 Activation: Upregulates the Nrf2 pathway, boosting the body’s endogenous production of powerful antioxidant enzymes (glutathione, SOD).
•  Neuroprotection: Supports Nerve Growth Factor (NGF) synthesis and protects neurons from oxidative damage and excitotoxicity.
•  Cell Signaling: Modulates the activity of enzymes involved in critical cellular functions like growth, differentiation, and survival.Benefits and Advantages:
• Sustained Cellular Energy: Dramatically enhances mitochondrial efficiency and density, leading to increased ATP production and reduced fatigue.
• Sharper Cognitive Function: Supports memory, focus, learning, and overall brain health by protecting neurons and promoting neurogenesis.
• Potent Antioxidant Defense: Provides exceptional, long-lasting protection against oxidative damage throughout the body.
• Cardiometabolic Support: Promotes healthy cardiovascular function and may support healthy blood sugar metabolism.
• Cellular Renewal: Encourages the growth and protection of healthy cells while mitigating damage.
• Synergistic Potential: Works powerfully alongside other mitochondrial nutrients like CoQ10/Ubiquinol.
• Safety Profile: Recognized as safe (GRAS status in the US) with minimal side effects at recommended doses.
• 
• Key Technical Specifications

• Items	Specifications
  Appearance	Reddish Brown Powder
  Identification(A233/A259)UV Absorbance(A322/A259)	0.90±0.09
  	0.56±0.03
  Loss on Drying	≤9.0%
  Heavy Metals	≤10ppm
  ARSENIC	≤2ppm
  Mercury	≤0.1ppm
  Lead	≤1ppm
  Sodium/PQQ ratio	1.7～2.1
  HPLC Purity	≥99.0%
  Total Aerobic Count	≤1000cfu/g
  Yeast and mold count	≤100cfu/g

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