Polynucleotide, Boost Skin Regeneration, Enhance Moisture Retention & Amplify Repair Capacity

Polynucleotide(PN)

Short Description:

PN (Polynucleotide),the base composition of salmon DNA is highly consistent with that of human DNA, with a 98% similarity. Polynucleotide (PN) is produced by uniformly segmenting and finely extracting the salmon DNA that is most suitable for the human body using patented technology. It is delivered to the dermis layer of the skin, improves the internal physiological conditions of damaged skin, restores the skin’s internal environment to a normal state, and fundamentally solves skin problems.PN (Polynucleotide) is a cutting-edge bioactive compound in premium skincare, celebrated for its ability to boost skin repair, enhance hydration, and restore a youthful, healthy glow, making it a standout in high-performance cosmetic formulations.​


  • Trade Name: Cosmate®PN
  • Product Name: Polynucleotide
  • INCI Name: Polynucleotide
  • Function: Skin Regeneration
  • Product Detail

    Why Zhonghe Fountain

    Product Tags

    PN,  Polynucleotide, is a sophisticated biomolecule that has revolutionized the cosmetics industry with its remarkable skin-nourishing properties. Derived from carefully selected natural sources and processed through advanced purification techniques, this long-chain nucleotide polymer offers a science-backed solution for various skin concerns. In cosmetic applications, PN is valued for its exceptional compatibility with human skin, as its structure aligns closely with the body’s own nucleic acids, allowing for deep penetration and effective interaction with skin cells. Unlike many synthetic ingredients, PN works in harmony with the skin’s natural processes, delivering gentle yet powerful results. Whether in serums, masks, or creams, PN contributes to a visibly healthier complexion by addressing the root causes of skin damage and aging, making it a must-have ingredient for those seeking transformative skincare outcomes.​PN is the secondary refined product of the initial PDRN, with a more stable long-chain molecular structure. It has a molecular weight of 1000 kDa, belonging to a macromolecular structure, and features a three-dimensional scaffold structure, namely a double-helix three-dimensional support structure.

    组合1

    Key Function​ of Polynucleotide

    Stimulates skin cell regeneration and turnover for a fresher, more youthful appearance.​

    Enhances the skin’s natural moisture barrier, locking in hydration for long-lasting suppleness.​

    Reduces the appearance of fine lines, wrinkles, and uneven texture by boosting collagen production.​

    Calms and soothes irritated or sensitive skin, minimizing redness and discomfort.​

    Improves skin elasticity and firmness, restoring a lifted, toned look.​

    Mechanism of Action​ ​ of Polynucleotide

    PN exerts its beneficial effects on the skin through a multi-faceted mechanism. When applied topically, it penetrates the stratum corneum and interacts with fibroblasts, the key cells responsible for producing collagen and elastin. This interaction triggers a signaling pathway that activates fibroblast activity, leading to increased synthesis of these structural proteins, which are vital for maintaining skin’s elasticity and firmness. Additionally, PN promotes the production of hyaluronic acid, a natural moisturizer in the skin, enhancing its ability to retain water and stay plump. It also modulates the skin’s inflammatory response by inhibiting pro-inflammatory cytokines, reducing redness and sensitivity. Furthermore, PN supports the skin’s natural repair process by encouraging cell proliferation, helping to replace damaged cells with new, healthy ones, resulting in a smoother, more radiant complexion over time.​

    Benefits and Advantages​ ​ of Polynucleotide

    Natural Compatibility: Works with the skin’s biology, reducing the risk of irritation, suitable for most skin types including sensitive skin.​

    Comprehensive Anti-Aging: Targets multiple signs of aging such as wrinkles, sagging, and dullness for holistic rejuvenation.​

    Long-Term Results: Supports the skin’s natural repair and regeneration processes, leading to sustained improvements.​

    Deep Hydration: Boosts the skin’s moisture-retention capacity, keeping it hydrated and supple throughout the day.​

    Strengthens Skin Barrier: Enhances the skin’s protective layer, making it more resilient against environmental stressors like pollution and UV rays.​

    Visible Improvement: Delivers noticeable results in skin texture, tone, and radiance with consistent use.​

    Key Technical Specifications

     ITEMS

    SPECIFICATION

    Appearance White, white-like or light yellow powder
    Solubility Slightly soluble in water
    Identification UV:Ratio of absorbance at 260 and 280nm 1.5-2.0
    Loss on Drying 20.0% max.
    pH Value (1% aqueous solution) 5.0~9.0
    Assay 95.0% min
    Average molecular weight 1000 KDa min
    Protein content (Foline-phenol method) <1.0%
    Heavy metal content ≦10ug/g
    Transmittance(0.5%solution,550nm ) ≧96.0%
    Ethanol Residue <0.5%
    Bacterial endotoxin <0.5EU/mg
    Total aerobic bacteria count ≦100cfu/g
    Mold and Yeast count ≦100cfu/g
    Escherichia coli Negative/g
    Staphylococcus aureus Negative/g
    Pseudomonas aeruginosa Negative/g

    Appliacation:

    Anti-Aging Serums: Concentrated PN serums for targeted treatment of fine lines, wrinkles, and loss of firmness.​

    Hydrating Masks: PN-infused masks for intensive moisture boost and skin revitalization, ideal for weekly pampering.​

    Daily Moisturizers: Day and night creams containing PN to provide ongoing hydration and anti-aging support.​

    Post-Treatment Products: Used after procedures like chemical peels or microdermabrasion to soothe and accelerate skin recovery.​

    Eye Creams: Formulations with PN to address fine lines, dark circles, and puffiness around the delicate eye area.​

    Sensitive Skin Care: Gentle lotions and creams with PN to calm irritation and strengthen the skin barrier for sensitive or reactive skin.​


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