NAD＋

Short Description:

NAD+ (Nicotinamide Adenine Dinucleotide) is an innovative cosmetic ingredient, valued for boosting cellular energy and aiding DNA repair.As a key coenzyme, it enhances skin cell metabolism, countering age-related sluggishness. It activates sirtuins to repair damaged DNA, slowing photoaging signs. Studies indicate NAD+-infused products boost skin hydration by 15-20% and reduce fine lines by ~12%. It often pairs with Pro-Xylane or retinol for synergistic anti-aging effects.Due to poor stability, it requires liposomal protection. High doses may irritate, so 0.5-1% concentrations are advised. Featured in luxury anti-aging lines, it embodies “cellular-level rejuvenation.”

Trade Name: Cosmate® NAD＋

Product Name: NAD＋

INCI Name: NAD＋

Molecular Formula: C21H27N7O14P2

CAS No.: 53-84-9

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Product Detail

Why Zhonghe Fountain

Product Tags

NAD+ (Nicotinamide Adenine Dinucleotide) is an emerging star in cosmetic ingredients, celebrated for its role in cellular energy metabolism and DNA repair.As a vital coenzyme, it fuels the tricarboxylic acid cycle to energize skin cells, mitigating the metabolic slowdown associated with aging. It also activates sirtuins—key deacetylases—to mend damaged DNA, effectively delaying photoaging.

Clinical findings show NAD+-containing skincare boosts stratum corneum hydration by 15%-20% and reduces fine line depth by approximately 12%. It frequently synergizes with ingredients like Pro-Xylane or retinol to amplify anti-aging effects.

Notably, its instability demands protection via liposomal encapsulation. High concentrations may cause irritation, so starting with 0.5%-1% is recommended. Now a staple in premium anti-aging lines, NAD+ epitomizes the “cellular anti-aging” trend.

Benefits of NAD＋

In cosmetics, NAD+ (Nicotinamide Adenine Dinucleotide) delivers targeted anti-aging benefits by revitalizing cellular function. As a key coenzyme, it boosts mitochondrial energy production in skin cells, combating age-related sluggishness to restore radiance and firmness.

It activates sirtuins, proteins that repair DNA damage from UV exposure and environmental stress, reducing fine lines, dullness, and uneven tone linked to photoaging.

NAD+ also strengthens the skin barrier, enhancing moisture retention and resilience against external aggressors. When paired with ingredients like retinol or peptides, it amplifies anti-aging synergy, making it a premium choice in formulations targeting mature or stressed skin.

NAD mechanism of Action

NAD+ (Nicotinamide Adenine Dinucleotide) exerts its effects through multiple key mechanisms, particularly in cellular energy metabolism and anti-aging processes.

As a vital coenzyme, it participates in redox reactions, shuttling electrons between molecules to facilitate ATP production in mitochondria—the cell’s “powerhouse”—thus boosting cellular energy levels, which decline with age. This energizes skin cells, enhancing their metabolic activity and repair capabilities.

Crucially, NAD+ activates sirtuins (a family of proteins), which regulate gene expression related to aging. Sirtuins use NAD+ as a cofactor to deacetylate target proteins, promoting DNA repair, reducing oxidative stress, and inhibiting cellular senescence. This helps counteract damage from UV rays and environmental pollutants, slowing visible signs of aging like wrinkles and dullness.

Additionally, NAD+ supports the skin barrier by aiding in lipid synthesis, improving moisture retention and resilience. Its role in maintaining cellular homeostasis makes it a core ingredient in anti-aging cosmetics.

Advantages of NAD

Revitalizes Cellular Energy: As a key coenzyme in mitochondrial energy production, it boosts skin cells’ metabolic activity, countering age-related sluggishness. This restores a brighter, more vibrant complexion by enhancing cellular turnover and nutrient utilization.
Enhances DNA Repair: By activating sirtuins (proteins that regulate aging), NAD+ accelerates the repair of DNA damage caused by UV rays, pollution, and oxidative stress. This reduces the accumulation of visible signs like fine lines, uneven texture, and hyperpigmentation.
Strengthens Skin Barrier: It supports lipid synthesis in the stratum corneum, improving moisture retention and resilience. This helps the skin defend against external aggressors (e.g., harsh weather, irritants) and maintain a plump, hydrated appearance.
Synergizes with Other Ingredients: When paired with anti-aging components like retinol, peptides, or hyaluronic acid, NAD+ amplifies their efficacy, creating formulations that address multiple aging pathways simultaneously.

Key Technical Specifications

Parameter	Details
CAS Number	53 – 84 – 9
Molecular Formula	C₂₁H₂₇N₇O₁₄P₂
Molecular Weight	663.43 g/mol
Appearance	Colorless to slightly yellowish freeze – dried substance
Solubility	Transparent, colorless to slightly yellowish aqueous solution (c = 200 mg/mL)
β – NAD (Enzymatic, A340)	≥94.5%
NAD (A260, ε = 17.6 (L×mmol⁻¹×cm⁻¹))	≥94.5%