Mono-Ammonium Glycyrrhizinate

Mono-Ammonium Glycyrrhizinate is the monoammonium salt of glycyrrhizic acid, derived from licorice extract. It exhibits anti-inflammatory, hepatoprotective, and detoxifying properties. Widely used in pharmaceuticals, it aids in treating liver diseases like hepatitis. In food, it serves as a flavoring and antioxidant. In cosmetics, it offers soothing effects. Its natural origin and versatile benefits make it valuable across the pharmaceutical, food, and cosmetic industries.

Key Functions of Mono-Ammonium Glycyrrhizinate

• Soothing and anti-irritation: It alleviates skin redness, itching, and discomfort caused by external stimuli (such as UV exposure, harsh ingredients, or environmental factors), making it suitable for sensitive or irritated skin.
• Anti-inflammatory action: Inhibits the release of inflammatory mediators, reducing skin inflammation and swelling, which helps calm conditions like acne-related redness or post-procedure irritation.
• Antioxidant protection: Scavenges free radicals, combating oxidative damage to the skin, slowing down signs of aging (e.g., dullness, fine lines) and enhancing skin resilience.
• Moisturizing and conditioning: Aids in maintaining skin hydration balance, leaving the skin soft and supple without greasiness, suitable for various skin types.
• Enhancing skin barrier function: Supports the repair of the skin’s protective barrier, reducing transepidermal water loss and improving overall skin health.

Mechanism of Action of Mono-Ammonium Glycyrrhizinate

• Anti-inflammatory & soothing mechanism:
  It inhibits the activity of phospholipase A2 and cyclooxygenase (COX) — key enzymes involved in the production of inflammatory mediators (e.g., prostaglandins, leukotrienes). By reducing the release of these pro-inflammatory substances, it alleviates redness, itching, and irritation caused by external stimuli (e.g., UV, harsh chemicals).
• Antioxidant protection:
  It scavenges reactive oxygen species (ROS) and free radicals, which are generated by UV radiation, pollution, or metabolic processes. This reduces oxidative stress, prevents lipid peroxidation in skin cells, and protects collagen and elastin from damage, thereby delaying skin aging and maintaining skin vitality.
• Skin barrier repair:
  It promotes the synthesis of ceramides and other lipids in the stratum corneum, strengthening the skin’s protective barrier. This enhances the skin’s ability to retain moisture (reducing transepidermal water loss) and resists external irritants, improving overall skin resilience, especially for sensitive or barrier-damaged skin.
• Mild whitening auxiliary effect:
  It indirectly helps reduce pigmentation by inhibiting inflammation-induced melanin overproduction, though this is secondary to its primary soothing and anti-inflammatory roles

Benefits and Advantages of Mono-Ammonium Glycyrrhizinate

• Multi-functional efficacy: Combines anti-inflammatory, soothing, antioxidant, and barrier-repairing properties, addressing multiple skin concerns (e.g., sensitivity, redness, oxidative damage) in one ingredient.
• Gentle and skin-friendly: Suitable for sensitive, fragile, or post-procedure skin due to its mild nature, with low irritation potential compared to harsher anti-inflammatory agents.
• Natural origin: Derived from licorice extract, aligning with consumer preferences for natural, plant-based ingredients in cosmetics and pharmaceuticals.
• Stability and compatibility: Exhibits good stability in various formulations (creams, serums, lotions) and works well with other ingredients (e.g., vitamins, hyaluronic acid), enhancing formulation versatility.
• Broad applicability: Effective across skin types (dry, oily, combination) and can be used in diverse products (moisturizers, sunscreens, after-sun care, anti-aging serums).
• Support for long-term skin health: By strengthening the skin barrier and reducing chronic inflammation, it helps maintain skin resilience and prevents recurring sensitivity or damage.

Key Technical Parameters

Application

• Efficacy Enhancement: Integrated into formulations to deliver specific benefits—boosting microcirculation in eye care to reduce puffiness/dark circles; providing antioxidant protection in anti-aging products to combat free radical damage; and aiding mild lipolysis in body care to improve cellulite appearance.
• Formulation Versatility: Compatible with various bases (aqueous, oil-based, or emulsion systems) and common ingredients (hyaluronic acid, vitamins, peptides), enabling seamless incorporation into diverse products like serums, creams, lotions, and gels.
• Safety & Tolerance: Its mild nature and low irritation risk make it suitable for sensitive skin formulations, including those for delicate areas (e.g., under eyes, post-shave products).
• Market Alignment: As a plant-derived (cocoa-sourced) ingredient, it caters to clean beauty trends, enhancing the appeal of cosmetic lines focused on natural actives.

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