ipotassium Glycyrrhizinate(DPG),Natural anti-inflammatory and anti-allergic

Dipotassium Glycyrrhizinate(DPG)

Short Description:

Dipotassium Glycyrrhizinate(DPG), derived from licorice root, is a white to off – white powder. Renowned for its anti – inflammatory, anti – allergic, and skin – soothing properties, it has become a staple in high – quality cosmetic formulations.


  • Trade Name: Cosmate®DPG
  • Product Name: Dipotassium Glycyrrhizinate
  • INCI Name: Dipotassium Glycyrrhizinate
  • Molecular Formula: C42H60K2O16
  • CAS No: 68797-35-3
  • Product Detail

    Why Zhonghe Fountain

    Product Tags

    Dipotassium Glycyrrhizate (DPG) is a highly purified, water-soluble salt derived from Glycyrrhizic Acid, the primary active component of Licorice Root (Glycyrrhiza glabra). A cornerstone of advanced skincare science and a K-beauty favorite, DG delivers multifaceted benefits by targeting inflammation, hyperpigmentation, and skin barrier vulnerability. Its exceptional compatibility and stability make it a versatile powerhouse for formulations targeting sensitivity, redness, dullness, and signs of aging.

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    Key Function of  Dipotassium Glycyrrhizate (DPG)

    Anti – inflammatory​

    Effectively reduces redness, swelling, and irritation associated with various skin conditions. It can soothe skin inflammation caused by acne, sunburn, or contact dermatitis.​

    Anti – allergic​

    Helps to calm allergic reactions on the skin. It works by preventing the release of histamine, a compound in the body that triggers allergic symptoms such as itching, rash, and hives.​

    Skin Barrier Support​

    Assists in maintaining and strengthening the skin’s natural barrier function. This helps the skin retain moisture and protects it from external aggressors like pollutants and irritants.​

    Mechanism of Action for Dipotassium Glycyrrhizate (DPG)

    Anti – inflammatory Pathway: Dipotassium Glycyrrhizinate inhibits the activity of certain enzymes and cytokines involved in the inflammatory response. For example, it can suppress the production of pro – inflammatory cytokines such as interleukin – 6 (IL – 6) and tumor necrosis factor – alpha (TNF – α). By reducing the levels of these cytokines, it decreases the inflammatory signals in the skin, leading to a reduction in redness and swelling.​

    Anti – allergic Mechanism: As mentioned, it blocks the release of histamine from mast cells. Mast cells are key players in the allergic response. When the body is exposed to an allergen, mast cells release histamine, which causes the characteristic symptoms of an allergic reaction. By preventing this release, Dipotassium Glycyrrhizinate alleviates allergic symptoms on the skin.​

    Skin Barrier Enhancement: It helps to regulate the synthesis of lipids in the skin, specifically ceramides. Ceramides are essential components of the skin’s barrier. By promoting ceramide production, Dipotassium Glycyrrhizinate improves the integrity of the skin barrier, enhancing its ability to retain moisture and resist external stressors.​

    Benefits and Advantages of Dipotassium Glycyrrhizate (DPG)

    Gentle on Sensitive Skin: Due to its anti – inflammatory and anti – allergic properties, it is extremely suitable for sensitive skin types. It can soothe and calm irritated skin without causing further irritation.​

    Versatile in Formulations: Its high water solubility allows it to be easily incorporated into a wide range of cosmetic products, from light – weight water – based serums to rich, creamy moisturizers.​

    Natural Origin: Being derived from licorice root, it offers a natural alternative for consumers who prefer products with natural ingredients.​

    Long – established Safety Profile: Extensive research and years of use in the cosmetic and pharmaceutical industries have established its safety for topical application.

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    Key Technical Parameters

    Items

    Specification

    Appearance White or yellowish fine powder
    Loss on Drying NMT 8.0%
    Residue on Ignition 18.0%-22.0%
    pH 5.0 – 6.0
    Heavy Metals
    Total Heavy Metals NMT 10 ppm
    Lead NMT 3 ppm
    Arsenic NMT 2 ppm
    Microbiology
    Total Plate Count NMT 1000 cfu/gram
    Mold & Yeast NMT 100cfu/gram
    E. Coli Negative
    Salmonella Negative

     

    Application

    Moisturizers: In both day and night creams, lotions, and body butters, Dipotassium Glycyrrhizinate helps to soothe the skin while enhancing its moisture – retaining capacity.​

    Sunscreens: It can be added to sunscreen formulations to reduce the skin’s inflammatory response to UV radiation, providing an extra layer of protection against sunburn and long – term sun damage.​

    Anti – acne Products: By reducing inflammation and soothing irritated skin, it is beneficial in acne – fighting products. It can help to calm the redness and swelling associated with acne breakouts.​

    Eye Creams: Given its gentle nature, it is suitable for use in eye creams to reduce puffiness and soothe the delicate skin around the eyes.​

    Hair Care Products: Some shampoos and conditioners also contain Dipotassium Glycyrrhizinate to soothe the scalp, especially for those with sensitive scalps or scalp conditions like dandruff – related inflammation.​

     


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