Glabridin

Glabridin stands out as one of the most bioactive compounds in licorice extract, prized for its scarcity and versatility. Only a very small amount of glabridin can be extracted from 1 ton of licorice roots. its extraction is highly intricate, contributing to its premium status. Unlike many traditional brightening ingredients, glabridin offers a unique combination of efficacy and mildness: it powerfully inhibits melanin production while soothing irritated skin and combating free radicals, making it suitable even for sensitive and delicate skin types.​

In cosmetic applications, glabridin excels at addressing multiple skin concerns simultaneously. It targets hyperpigmentation such as sun spots, melasma, and post-acne marks, evens out uneven skin tone, and enhances radiance. Beyond brightening, its anti-inflammatory properties calm redness and sensitivity, while its antioxidant capacity helps delay signs of aging, making it a multi-tasking ingredient that fulfills “brightening + repairing + anti-aging” needs.​

Key Functions​ of Glabridin

Potent Brightening & Spot Reduction: Inhibits tyrosinase activity (a key enzyme in melanin synthesis), reducing melanin production, fading existing spots, and preventing new pigmentation.​

Anti-Inflammatory & Soothing: Reduces the release of pro-inflammatory cytokines (e.g., IL-6, TNF-α), alleviating skin redness and sensitivity, and repairing the skin barrier.​

Antioxidant & Anti-Aging: Scavenges free radicals, minimizes oxidative damage to the skin, and delays aging signs like fine lines and sagging.​

Skin Tone Regulation: Improves uneven skin tone, boosts skin translucency, and promotes a naturally fair and healthy complexion.​

Mechanism of Action​ of Glabridin

Melanin Synthesis Inhibition: Competitively binds to the active site of tyrosinase, directly blocking the formation of melanin precursors (dopaquinone) and preventing pigment accumulation at the source.​

Anti-Inflammatory Repair Pathway: Inhibits the NF-κB inflammatory signaling pathway, reducing inflammation-induced pigmentation (e.g., acne marks) and promoting stratum corneum repair to enhance skin resistance.​

Antioxidant Protection: Its molecular structure captures and neutralizes free radicals, protecting collagen and elastic fibers from oxidative damage, thus maintaining skin elasticity and firmness.​

Benefits and Advantages​ of Glabridin

Gentle & Safe: Non-cytotoxic with extremely low skin irritation, suitable for all skin types, including sensitive skin and pregnant skin.​

Multi-Functional: Combines brightening, anti-inflammatory, and antioxidant effects, enabling comprehensive skincare without the need for multiple ingredients.​

High Stability: Resistant to light and heat, maintaining its activity in cosmetic formulations to ensure long-lasting efficacy.​

KEY TECHNICAL PARAMETERS

Applications:

Glabridin is widely used in various high-end skincare products, such as:​

Brightening Serums: As a core ingredient, specifically fading spots and enhancing radiance.​

Repairing Creams: Combined with moisturizing ingredients to soothe sensitivity and strengthen the skin barrier.​

Post-Sun Repair Products: Alleviating UV-induced inflammation and pigmentation.​

Luxury Masks: Providing intensive brightening and anti-aging care to improve overall skin quality.

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